• Murakami, S.; Nanjo, T.; Takemoto, Y.
    Photocatalytic Activation of Elemental Sulfur Enables a Chemoselective Three-Component Thioesterification

    Organic Letters, 2021, 23, 7650-7655.
    DOI: 10.1021/acs.orglett.1c02904
  • Tsukano, C.;* Yagita, R.; Heike, T.; Mohammed, T. A. A.; Nishibayashi, K.; Irie, K.; Takemoto, Y.*
    “Asymmetric Total Synthesis of Shagenes A and B”
    Angew. Chem. In. Ed., 2021, Early View.
    DOI: 10.1002/anie.202109786
  • Takemoto, Y.
    Review (invited): “Molecular Transformation Based on an Innovative Catalytic System”
    Chem. Pharm. Bull., 2021, 69 (9), 819–831.
  • 小林祐輔、竹本佳司(共著)、アミドのグリコシル化、月刊バイオインダストリー「第三の生命鎖「糖鎖」を構築する合成化学~グリコシル化の最前線~」、戸嶋一敦監修、シーエムシー出版、2021年8月12日(Vol.38, No.8, 2021), pp. 64-72. 90ページ
  • Kobayashi, Y.*; Masakado, S.; Murai, T.; Hamada, S.; Furuta, T.; Takemoto, Y.*
    “A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles”
    Org. Biomol. Chem., 2021, 19, 6628–6632.
    DOI: 10.1039/D1OB00947H
    Graphical abstract: A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles
  • Hayama, N.; Kobayashi, Y.; Takemoto, Y.*
    Review (invited): “Asymmetric hetero-Michael addition to α,β-unsaturated carboxylic acids using thiourea–boronic acid hybrid catalysts”
    Tetrahedron, 2021, 89, 132089.
    DOI: 10.1016/j.tet.2021.132089
    Image 1
  • Murakami, H.; Yamada, A.; Michigami, K.; Takemoto, Y.*
    “Novel aza-Michael addition–asymmetric protonation to ,-unsaturated carboxylic acids with chiral thiourea–boronic acid hybrid catalysts”
    Asian J. Org. Chem., 2021, 10 (5), 1097–1101.
    DOI: 10.1002/ajoc.202100145
  • Kurose, T.; Tsukano, C.*; Nanjo, T.; Takemoto, Y.*
    “Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core”
    Org. Lett. 2021, 23, 676-681.
    the top ten downloaded articles in Organic Letters in December 2020
    DOI: 10.1021/acs.orglett.0c03816
    Synfacts でハイライトされました。
  • Nakatsuji, Y.; Kobayashi, Y.; Masuda, S.; Takemoto, Y*.
    “Azolium/hydroquinone organo-radical co-catalysis: Aerobic C‒C-bond cleavage in ketones”
    Chem. Eur. J., 2021, 27, 2633-2637.
    DOI: 10.1002/chem.202004943
  • Tokuhiro Y.; Hayama N.; Kobayashi Y.; Takemoto Y.*
    “Bifunctional-Benzothiadiazine-Catalyzed Regio- and Stereoselective Aldol Reactions Using A 1,3-Acetonedicarboxylic Acid Monoester”
    Heterocycles, 2021, 103, 484-493.
    DOI: 10.3987/COM-20-S(K)12


  • Kobayashi, Y.; Takemoto, Y.*
    “Regio- and Stereoselective Glycosylation of 1,2-O-Unprotected Sugars Using Organoboron Catalysts”
    Tetrahedron, 2020, 76, 131328.
    DOI: 10.1016/j.tet.2020.131328
  • Izumi, S.; Kobayashi, Y.; Takemoto, Y.*
    “Stereoselective Synthesis of 1,1′-Disaccharides by Organoboron Catalysis”
    Angew. Chem. Int. Ed., 2020, 59, 14054-14059.
    DOI: 10.1002/anie.202004476
  • Yasui, M.; Yamada, A.; Tsukano, C.; Hamza, A.: Pápai, I.; Takemoto, Y.*
    “Enantioselective Acetalization by Dynamic Kinetic Resolution for the Synthesis of γ-Alkoxybutenolides by Thiourea/Quaternary Ammonium Salt Catalysts: Application to Strigolactones”
    Angew. Chem. Int. Ed., 2020, 59, 13479-13483.
    DOI: 10.1002/anie.202002129

  • Hayama, N.; Kobayashi, Y.; Sekimoto, E.; Miyazaki, A.; Inamoto, K.; Kimachi, T.; Takemoto, Y.*
    “A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst”
    Chem. Sci., 2020, 11, 5572-5576.
    DOI: 10.1039/D0SC01729A

  • Saito, M.; Murakami, S.; Nanjo, T.; Kobayashi, Y.; Takemoto, Y.*
    Mild and Chemoselective Thioacylation of Amines Enabled by the Nucleophilic Activation of Elemental Sulfur
    J. Am. Chem. Soc. 2020, 142, 8130-8135.
    DOI: 10.1021/jacs.0c03256
  • Masakado, S.; Kobayashi, Y.*; Takemoto, Y.*
    Photo-Irradiation-Promoted Aminoetherification of Glycals with N-Acyliminoiodinane and Alcohols
    Heterocycles, 2020, 101, 453-460.
    DOI: 10.3987/COM-19-S(F)25
  • Kobayashi, Y.*; Takemoto, Y.*
    “Reactions Catalyzed by 2-Halogenated Azolium Salts: From Halogen-Bond Donors to Brønsted-Acidic Salts”
    Synlett, 2020, 31, 772-783.
    DOI: 10.1055/s-0039-1690815


  • Michigami, K.; Sakaguchi, T.; Takemoto, Y.*
    “Catalytic Dehydrative Peptide Synthesis with gem-Diboronic Acids”
    ACS Catal., 2020, 10, 683-688.
    DOI: 10.1021/acscatal.9b03894
  • Nanjo, T.; Kato, N.; Zhang, X.; Takemoto, Y.*
    “A Hydroperoxide‐Mediated Decarboxylation of α‐Ketoacids Enables the Chemoselective Acylation of Amines”
    Chem. Eur. J., 2019, 25,
    DOI: 10.1002/chem.201904717
  • Nakamura, H.; Kawakami, M.; Tsukano, C.; Takemoto, Y.
    “Concise Construction of ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetra-substituted Olefin”
    Synlett 2019, 30, 2253-2257.
    DOI: 10.1055/s-0039-1690267
  • Nanjo, T.; Zhang, X.; Tokuhiro, Y.; Takemoto, Y.*
    “Divergent and Scalable Synthesis of α-Hydroxy/Keto-β-amino Acid Analogues by the Catalytic Enantioselective Addition of Glyoxylate Cyanohydrin to Imines”
    ACS catal., 2019, 9, 10087-10092.
    DOI: 10.1021/acscatal.9b03394

  • Nakatsuji, Y.; Kobayashi, Y.; Takemoto, Y.*
    “Direct addition of Amides to Glycals Enabled by Solvation-insusceptible 2-Haloazolium Salt Catalysis”
    Angew. Chem. Int. Ed., 2019, 58, 14115-14119.
    DOI: 10.1002/anie.201907129
    Highlighted in Synfacts 2019, 15, 1318.

  • Saito, M.; Kobayashi, Y.; Takemoto, Y.*
    “Divergent and Chemoselective Transformations of Thioamides with Designed Carbene Equivalents”
    Chem. Eur. J. 2019, 25, 10314-10318.
    DOI: 10.1002/chem.201902699
  • Nakamura, H.; Tsukano, C.*; Yoshida, T.; Yasui, M.; Yokouchi, S.; Kobayashi, Y.; Igarashi, M.; Takemoto, Y.*
    “Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone”
    J. Am. Chem. Soc. 2019, 141, 8527-8540.
    DOI: 10.1021/jacs.9b02220
  • Nakamura, H.; Kawakami, M.; Tsukano, C.; Takemoto, Y.
    Concise construction of the ACDE ring system of calyciphylline A-type alkaloids via [5+2] cycloaddition”
    Chem. Eur. J. 2019, 25, 8701-8704.
    DOI: 10.1002/chem.201901690

  • Michigami, K.; Murakami, H.; Nakamura, T.+; Hayama, N.; Takemoto, Y.
    “Catalytic asymmetric aza-Michael addition of fumaric monoacids with multifunctional thiourea/boronic acids”
    Org. Biomol. Chem. 2019, 17, 2331-2335.
    DOI: 10.1039/C9OB00045C

    This paper is dedicated to our talented colleague, Mr. Takeru Nakamura, who passed away on 25th Oct, 2017.

  • Izumi, S.; Kobayashi, Y.; Takemoto, Y.
    “Regio- and Stereoselective Synthesis of 1,2-cis-Glycosides by Anomeric O-Alkylation with Organoboron catalysis”
    Org. Lett. 201921, 665-670.
    DOI: 10.1021/acs.orglett.8b03823


  • Tsukano, C.*; Nakajima, M.; Hande, S. M.; Takemoto, Y.*
    “Palladium-catalyzed intramolecular carboborylation of 1,3-diene and synthesis of ABCD ring of communesins”
    Org. Biomol. Chem. 2019, 17, 1731-1735.
    DOI: 10.1039/c8ob02224k

  • Ikota, H.; Tsukano, C.; Takemoto, Y.
    “Concise and Scalable Synthesis of (±)-Aurantioclavine”
    Heterocycles 201897, 621-631.
    DOI: 10.3987/COM-18-S(T)49

  • Yasui, M.; Ota, R.; Tsukano, C.; Takemoto, Y.
    “Synthesis of cis-/All-cis-Substituted Cyclopropanes through Stereocontrolled Metalation and Pd-Catalyzed Negishi Coupling”
    Org. Lett.201820, 7656-7660.
    DOI: 10.1021/acs.orglett.8b03390

  • Hayama, N.; Kuramoto, R.; Földes, T.; Nishibayashi, K.; Kobayashi, Y.; Pápai, I.; Takemoto, Y.
    “Mechanistic Insight into Asymmetric Hetero-Michael Addition of α,β-Unsaturated Carboxylic Acids Catalyzed by Multifunctional Thioureas”
    J. Am. Chem. Soc. 2018140, 12216-12225.
    DOI: 10.1021/jacs.8b07511

  • Nanjo, T.; Kato, N.; Takemoto, Y.; Oxidative Decarboxylation Enables Chemoselective, Racemization-Free Esterification: Coupling of α-Ketoacids and Alcohols Mediated by Hypervalent Iodine(Ⅲ)
    Org. Lett. 201820, 5766-5769.
    DOI: 10.1021/acs.orglett.8b02466

  • Li, S.; Kobayashi, Y.; Takemoto, Y.; Organocatalytic Direct α-Selective N-Glycosylation of Amide with Glycosyl Trichloroacetimidate, Chem. Pharm. Bull. 201866, 768-770.
    DOI: 10.1248/cpb.c18-00255

  • Masakado, S.; Kobayashi, Y.; Takemoto, Y.; Photo-induced aziridination of alkenes with N-sulfonyliminoiodinanes, Chem. Pharm. Bull. 201866, 688-690.
    DOI: 10.1248/cpb.c18-00198

  • Kobayashi,Y.; Nakatsuji, Y.; Li, S.; Tsuzuki, S.; Takemoto, Y.; Direct N-Glycofunctionalization of Amides with Glycosyl Trichloroacetimidate by Thiourea/Halogen Bond Donor Co-Catalysis, Angew. Chem. Int. Ed. 201857, 3646-3650. 
    DOI: 10.1002/anie.201712726

  • Kobayashi, Y.; Masakado, S.; Takemoto, Y*. Photoactivated N-Acyliminoiodinanes Applied to Amination: an ortho-Methoxymethyl Group Stabilizes Reactive Precursors, Angew. Chem. Int. Ed.201857, 693-697.


  • Tsukano, C.; Suetsugu, S.; Muto, N.; Takemoto Y.;Synthesis of Tetrahydrobiphenylene via Pd(0)-Catalyzed C(sp2)-H Functionalization, Chem. Pharm. Bull.201765, 1167-1174. 
    (Highlighted paper selected by Editor-in-ChiefおよびFeatured Articleに選定されました。)

  • Yasui, M.; Ota, R.; Tsukano, C.*; Takemoto, Y.* Total synthesis of avenaol, Nat. Commun.20178, 674.
    Nat. Commun. おすすめコンテンツ
    Editor’s collection “Synthetic and Medicinal Chemistry”に掲載されました。

  • Kurose, T.; Tsukano, C.; Takemoto, Y. Synthesis of Octahydro- and Decahydroquinolines by a One-Pot Cascade Reaction of Tetrasubstituted Enecarbamate, Org. Lett.201719, 4762-4765.

  • Electrophilic Activation of Iodonium Ylides by Halogen-Bond-Donor Catalysis for Cross-Enolate Coupling, Saito, M.; Kobayashi, Y.; Tsuzuki, S.; Takemoto, Y. Angew. Chem. Int. Ed.201756, 7653-7657.
    同誌のVery Important Paperに選出されました

  • Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction, Taryn, M.; Murata, A.; Kobayashi, Y.; Takemoto, Y. Synlett, 2017, 28, 1295.


  • An Enantioselective Synthesis of 2-Imidazolidinones through Bifunctional Thiourea-Catalyzed Tandem Mannich/Cyclization of Isocyanatomalonate Diester, Kobayashi Y.;, Yoshida, T.; Uno, Y.; Tsukano, C.; Takemoto, Y. Heterocycles, 2017, 95, 980.

  • Competent route to the unsymmetric dimer architectures: Total syntheses of (-)-lycodine, (-)-complanadines A and B, and evaluation of their neurite outgrowth activities, Zhao, L.; Tsukano, C.; Kwon, E.; Shirakawa, H.; Kaneko, S.; Takemoto, S.; Hirama, M. Chem. Eur. J. 2017,23, 802.同誌のVery Important Paperに選出されました

  • Nanjo, T.; Tsukano, C.; Takemoto, Y., Palladium-Catalyzed Double C-H Functionalization of Arenes at the Positions ortho and meta to their Directing Group: Concise Synthesis of Benzocyclobutenes, Chem. Pharm. Bull. 64, 1384-1392 (2016).

  • Chiral Integrated Catalysts Composed of Bifunctional Thiourea and Arylboronic Acid: Asymmetric Aza-Michael Addition of α,β-Unsaturated Carboxylic Acids, Noboru Hayama, Takumi Azuma, Yusuke Kobayashi, Yoshiji Takemoto, Chem. Pharm. Bull. 2016, 64, 704. 

  • Synthesis and Application of Tetrahydro-2H-fluorenes by a Pd(0)-Catalyzed Benzylic C(sp3)-H Functionalization, Satoshi Suetsugu, Nobusuke Muto, Misa Horinouchi, Dr. ChihiroTsukano, Prof.Dr. Yoshiji Takemoto, Chem. Eur. J. 2016, 22, 8059.
    DOI: 10.1002/chem.201601086

  • Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide, Hugh Nakamura, Takuma Yoshida, Chihiro Tsukano, Yoshiji Takemoto, Org. Lett. 2016, 18, 2300.
    DOI: 10.1021/acs.orglett.6b00943

  • Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives, Sanae Izumi, Yusuke Kobayashi, Yoshiji Takemoto, Org. Lett. 2016, 18, 696.DOI: 10.1021/acs.orglett.5b03666


  • Catalytic asymmetric formal synthesis of beraprost, Yusuke Kobayashi, Ryuta Kuramoto, Yoshiji Takamoto, Beilstein J. Org. Chem. 2015, 11, 2654. 
    DOI: 10.3762/bjoc.11.285

  • Synthetic Studies towards Communesins: Diastereoselective Oxidative Rearrangement of Aurantioclavine Derivatives, Satoshi Suetsugu, Chihiro Tsukano, Yoshiji Takemoto, Eur. J. Org. Chem. 2016, 108. 
    DOI: 10.1002/ejoc.201501194 

  •  Synthesis of α-Acyloxyketone Derivatives via the Platinum-Catalyzed Migration of Propargylic Esters, Chihiro, Tsukano, Sho, Yamamoto, Yoshiji Takemoto, Chem. Pharm. Bull. 63, 710-719 (2015). 
    DOI: 10.1248/cpb.c15-00417

  • Direct Dehydroxylative Coupling Reaction of Alcohols with Organosilanes through Si-X Bond Activation by Halogen Bonding, Masato Saito, Nobuya Tsuji, Dr. Yusuke Kobayashi, Prof. Yoshiji Takemoto, Org. Lett. 2015, 17, 3000. 
    DOI: 10.1021/acs.orglett.5b01290

  • Total Synthesis of (-)-Caprazamycin A, Hugh Nakamura, Dr. Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Dr. Masayuki Igarashi and Prof. Dr. Yoshiji Takemoto. Angew. Chem. Int. Ed. 2015, 54, 3136. 
    DOI: 10.1002/anie.201411954


  • Synthetic Approaches to Spiro-oxindoles and Iminoindolines Based on Formation of C2-C3 Tsukano, C.; Takemoto, Y. Heterocycles, 2014, 89, 2271. 
    DOI: 10.3987/REV-14-805KURENAI

  • Electrophilic iodine(I) compounds induced semipinacol rearrangement via C-X bond cleavage, Nobuya Tsuji, Dr. Yusuke Kobayashi, and Prof. Yoshiji Takemoto, Chem. Commun., 2014, 50, 13691. 
    DOI: 10.1039/C4CC06014H

  • Catalytic asymmetric synthesis of the pentacyclic core of (-)-nakadomarin A via oxazolidine as an iminium cation equivalent, Nobuya Tsuji, Micheal Stadler, Naoya Kazumi, Dr. Tsubasa, Inokuma, Dr. Yusuke Kobayashi, and Prof. Yoshiji Takemoto, Org. Biomol. Chem., 2014, 12, 7919. 
    DOI: 10.1039/C4OB01678E

  • Asymmetric Synthesis of Trisubstituted Oxazolidinones by the Thiourea-Catalyzed Aldol Reaction of 2-Isocyanatomalonate Diester, Shota sakamoto, Naoya Kazumi, Dr. Yusuke Kobayashi, Dr. Chihiro Tsukano, and Prof. Yoshiji Takemoto, Org. Lett., 2014, 16, 4758. 
    DOI: 10.1021/ol502198e

  • Synthesis of Pyrrolophenanthridine Alkaloids Based on C(sp3)-H and C(sp2)-H Functionalization Reactions, Dr. Chihiro Tsukano, Nobusuke Muto, Iderbat Enkhtaivan, Prof. Yoshiji, Takemoto, Chem. Asian J. 2014, 9, 2628. 
    DOI: 10.1002/asia.201402490

  • A Dual Arylboronic Acid-Aminothiourea Catalytic System for the Asymmetric Intramolecular Hetero-Michael Reaction of α,β-Unsaturated Carboxylic Acids, Takumi Azuma, Akihiro Murata, Yusuke Kobayashi, Tsubasa Inokuma, and Yoshiji Takemoto, Org. Lett., 2014, 16(16), 4256-4259 
    DOI: 10.1021/ol501954r

  • Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene, Hideo Ikota, Takayuki Ishida, Chihiro Tsukano and Yoshiji Takemoto, Chem. Commun., 2014, 50, 8871-8874 
    DOI: 10.1039/C4CC04047C

  • Equilibration of the [2+2] Cycloaddition of Silyl Enol Ethers Catalyzed by Ethylaluminium Dichloride: Diastereoselectivity Switch in the Synthesis of Fused Cyclobutanes, Kenji Hata, Norihito Arichi, Dr. Yousuke Yamaoka, Dr. Ken-ichi Yamada, Prof.Dr. Yoshiji Takemoto and Prof.Dr. Kiyosei Takasu, Asian. J. Org. Chem., 2014, 3(6), 706 
    DOI: 10.1002/ajoc.201402042

  • Palladium(0)-Catalyzed Carbon-Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones, Chihiro Tsukano, Masataka Okuno, Hiromi Nishiguchi and Yoshiji Takemoto, Adv. Synth. Catal., 2014, 356(7), 1533 
    DOI: 10.1002/adsc.201400078

  • Synthesis of 3,3-Disubstituted 2-Aminoindolenines by Palladium-Catalyzed Allylic Amidination with Isocyanide, Takeshi Nanjo, Chihiro Tsukano, Yoshiji Takemoto, Synlett, 2014, 25(10), 1473 
    DOI: 10.1055/s-0033-1341241

  • Oxidant-Resistant Hydrogen-Bond-Donating Organocatalyst for Enantioselective Nucleophilic Epoxidation of α,β-Unsaturated Amides, Yusuke Kobayashi, Shanji Li, Yoshiji Takemoto, Asian. J. Org. Chem., 2014, 3(4), 403 

  • A diversity-oriented synthesis of caroverine derivatives via TEMPO-promoted aerobic oxidative C-N bond formation, Yusuke Kobayashi, Yusuke Suzuki, Tokutaro Ogata, Tetsutaro Kimachi, Yoshiji Takemoto, Tetrahedron Lett., 2014, 55(22), 3299 
    DOI: 10.1016/j.tetlet.2014.03.061

  •  Synthetic Study of Matrine-Type Alkaloids: Stereoselective Construction of the AB Rings of the Quinolizidine Skeleton, Chihiro Tsukano, Atsuko Oimura, Iderbat Enkhtaivan, Yoshiji Takemoto, Synlett, 2014, 25, 653-656 
    DOI: 10.1055/s-0033-1340179

  •  Synthesis and Characterization of Binary-Complex Models of Ureas and 1,3-Dicarbonyl Compounds: Deeper Insights into Reaction Mechanisms Using Snap-Shot Structural Analysis, Takumi Azuma, Yusuke Kobayashi, Ken Sakata, Takahiro Sasamori, Norihiro Tokitoh, Yoshiji Takemoto, J. Org. Chem., 2014, 79 (4), 1805-1817 
    DOI: 10.1021/jo4028775

  •  Asymmetric Synthesis of (-)-Aurantioclavine via Palladium-Catalyzed Intramolecular Allylic Amination, Satoshi Suetsugu, Hiromi Nishiguchi, Chihiro Tsukano, Yoshiji Takemoto, Org. Lett., 2014, 16 (3), 996-999. 
    DOI: 10.1021/ol4037314

  •  Long-Term Oral Administration of Hop Flower Extracts Mitigates Alzheimer Phenotypes in Mice, Norio Sasaoka, Megumi Sakamoto, Shoko Kanemori, Michiru Kan, Chihiro Tsukano, Yoshiji Takemoto, Akira Kakizuka., PLOS ONE, 9(1), e87185. 
    DOI: 10.1371/journal.pone.0087185


  • Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation,Takayuki Ishida, Hideo Ikota, Kei Kurahashi, Chihiro Tsukano, Yoshiji Takemoto, Angew. Chem. Int. Ed., 2013, 52(39), 10204-10207. 
    DOI: 10.1002/anie.201305581

  • A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of α,β-Unsaturated Amides and Esters,Yusuke Kobayashi, Yamato Taniguchi, Noboru Hayama, Tsubasa Inokuma, Yoshiji Takemoto, Angew. Chem. Int. Ed., 2013, 52(39), 11114-11118. 
    DOI: 10.1002/anie.201305492
    Synfacts, 2013, 9(11), 1230., 
    DOI: 10.1055/s-0033-1340025
    Synfacts, 2014, 10(1), 0006., 
    DOI: 10.1055/s-0033-1340325

  • Synthesis of 3-Acyl-2-arylindole via Palladium-catalyzed Isocyanide Insertion and Oxypalladation of Alkyne, Takeshi Nanjo, Sho Yamamoto, Chihiro Tsukano, and Yoshiji Takemoto, Org. Lett. 2013, 15, 3754-3757. 
    DOI: 10.1021/ol4016699

  • Synthesis of Spirooxindoles from Carbamoyl Chlorides via Cyclopropyl Methine C(sp3)-H Activation Using Palladium Catalyst, Chihiro Tsukano, Masataka Okuno, Yoshiji Takemoto, Chem. Lett., 2013, 42, 753-755. 

  • 複素環骨格を基盤とする新規水素結合供与型有機分子触媒の開発と不斉反応への応用, 小林祐輔, 猪熊翼, 竹本佳司, 有機合成化学協会誌, 2013, 71 (5), 491-502. 

  • Synthetic study of perophoramidine: construction of pentacyclic core structure via SmI2-mediated reductive cyclization, Takayuki Ishida, Yoshiji Takemoto, Tetrahedron, 2013, 69, 4517-4523. 

  • pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols, Yuuki Nagamoto, Akira Hattori, Hideaki Kakeya, Yoshiji Takemoto and Kiyosei Takasu, Chem. Commun., 2013, 49, 2622-2624. 

  • Study of Ring-Opening Reaction of Spiro[5.2]octenes with Aqueous Hydrohalic Acid: Substituent Effect on the Regioselectivity. Y. Nagamoto, Y. Takemoto, K. Takasu, Synlett (24), 120-124 (2013) 
  • 生合成中間体を想定した二量体型天然物全合成 塚野千尋, 有機合成化学協会誌, 2013, 71, 946-947. 
    DOI: 10.5059/yukigoseikyokaishi.71.946


  • N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters, Takuya Uno, Yusuke Kobayashi, Yoshiji Takemoto, Beilstein J. Org. Chem. 2012, 8, 1499-1504 

  • Palladium-Catalyzed Cascade Process Consisting of Isocyanide Insertion and Benzylic C(sp3)-H Activation: Concise Synthesis of Indole Derivatives, Takeshi Nanjo, Chihiro Tsukano, and Yoshiji Takemoto, Org. Lett. 2012, 14, 4270-4273.
    DOI: 10.1021/ol302035j

  • Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition?cyclization?trapping reactions, H. Miyabe, R. Asada, Y. Takemoto, Org. Biomol. Chem., 2012, 10, 3519-3530. 

  • Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization-(2 + 2) cycloaddition, K. Inanaga, Y. Ogawa, Y. Nagamoto, A. Daigaku, H. Tokuyama, Y. Takemoto, K. Takasu, Beilstein J. Org. Chem., 2012, 8, 658-661.
  • Acid-Catalyzed [2 + 2] Cycloaddition at Room-Temperature with Suppression of Side Reactions by Using a Flow Microreactor System. Kei Kurahashi, Yoshiji Takemoto, and Kiyosei Takasu, ChemSusChem 2012, 5 (2), 270-273.
    DOI: 10.1002/cssc.201100373

  • Organocatalyzed Isomerization of a-Substituted Alkynoates into Trisubstituted Allenoates by Dynamic Kinetic Resolution, Tsubasa Inokuma, Masaya Furukawa, Yusuke Suzuki, Tetsutaro Kimachi, Yusuke Kobayashi, Yoshiji Takemoto, ChemCatChem 2012, 4, 983-985.
    DOI: 10.1002/cctc.201200065

  • Platinum Catalyzed 7-endo Cyclization of Internal Alkynyl Amides and its Application to Synthesis of the Caprazamycin Core, C. Tsukano, S. Yokouchi, A. L. Girard, T. Kuribayashi, S. Sakamoto, T. Enomoto, Y. Takemoto Org. Biomol. Chem., 2012,10, 6074-6086

  • Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I, C. Tsukano, A. Oimura, I. Enkhtaivan, Y. Takemoto, Org. Lett. 2012, 14 (7), 1902-1905.

  • Palladium-Catalyzed Amidation by Chemoselective C(sp3)H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor. C. Tsukano, M. Okuno, Y. Takemoto, Angew. Chem. Int. Ed., 2012, 51, 2763-2766.

  • NHC-catalyzed thioesterification of aldehydes by external redox activation. T. Uno, T. Inokuma, Y. Takemoto, Chem. Commun. 2012, 48, 1901-1903.

  • Synthesis of 2-Iminoinolines via Samarium Diiodide Mediated Reductive Cyclization of Carbodiimides T. Ishida, C. Tsukano, Y. Takemoto, Chem. Lett., 2012, 41(1), 44-46.


  • Organocatalytic Asymmetric Neber Reaction for the Synthesis of 2H-Azirine Carboxylic Esters. S. Sakamoto, T. Inokuma, and Y. Takemoto, Org. Lett., 2011, 13(24), 6374-6377.
  • Synthesis of Optically Active N-Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy-Thiourea Catalyst. T. Inokuma, Y. Suzuki, T. Sakaeda, and Y. Takemoto, Chem. Asian J. 2011, 6, 2902-2906.
  • Bifunctional Hydrogen-Bond Donors That Bear a Quinazoline or Benzothiadiazine Skeleton for Asymmetric Organocatalysis. T. Inokuma, M. Furukawa, T. Uno, Y. Suzuki, K. Yoshida, Y. Yano, K. Matsuzaki Y. Takemoto, Chem. Eur. J., 2011, 17,(37), 10470-10477. 
  • Formal (3+3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers. A. Takumi, T. Yoshiji, T, Kiyosei CHEMICAL & PHARMACEUTICAL BULLETIN 2011, 59 (9), 1190-1193 
  • Regio- and Enantioselective Allylic Substitution with Less Active N- or O-Nucleophiles Catalyzed by Iridium-Complex of Bis(oxazolinyl)pyridine M. Hideto, M. Katsuhiko, T. Yoshiji CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (9), 714-720 
  • Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines N. Shindoh, K. Kitaura, Y. Takemoto, K. Takasu, J. Am. Chem. Soc., 2011, 133, 8470-8473 
  • Control of 6-Exo and 7-Endo Cyclizations of Alkynylamides using Platinum and Bismuth Catalysts Anne-Lise Girard, Taro Enomoto, Shinsuke Yokouchi, Chihiro Tsukano and Yoshiji Takemoto, Chemistry – An Asian Journal, 2011, 6, 1321-1324 
  • Domino Pd-Catalyzed Heck-Type Cyclization and Bi-Catalyzed Hydroamination: Formal Syntheses of Elacomine and Isoelacomine. H. Kamisaki, T. Nanjo, C.Tsukano, Y. Takemoto, Chem. Eur. J., 2011, 17,(2), 626-633. 
  • Flexible Strategy for Syntheses of Spirooxindoles using Palladium-catalyzed Carbosilylation and Sakurai-type Cyclization Sudhir M. Hande, Motoyuki Nakajima, Haruhi Kamisaki, Chihiro Tsukano, and Yoshiji Takemoto, Organic Letters 2011, 13(7), 1828-1831. 
  • Synthetic studies of salinosporamide A through intramolecular hydroamidation of alkynes. H. Kamisaki, Y. Kobayashi, T. Kimachi, Y. Yasui, Y. Takemoto, J. Organomet. Chem. 2011, 696 (1), 42-45. 


  • Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole. K. Takasu, T. Azuma, I. Enkhtaivan, Y. Takemoto, Molecules, 2010, 15, 8327-8348.
  • Catalytic Asymmetric Synthesis of Both Enantiomers of 4 Substituted 1,4-Dihydropyridines with the Use of Bifunctional Thiourea-Ammonium Salts Bearing Different Counterions. K. Yoshida, T. Inokuma, K. Takasu, Y. Takemoto, Molecules, 2010, 15, 8305-8326.
  • Auto-tandem Catalysis: Facile Synthesis of Substituted Alkylidenecyclo-hexanones by Domino (4 + 2) Cycloaddition-Elimination Raction. K. Takasu, T. Tanaka, T. Azuma, Y. Takemoto, Chem. Commun., 2010, 46, 8246-8248. DOI:10.1039/C0CC03336G
  • Stereocontrolled Synthesis of Spiro[n.2]alkenes by Ring Contraction of Fused-Cyclobutanols. K. Takasu, Y. Nagamoto, Y. Takemoto, Chem. Eur. J., 16(28), 8427-8432, (2010). 
  • Synthetic Study toward Ecteinascidin 743: Concise Construction of the Diazabicyclo[3.3.1]nonane Skeleton and Assembly of the Pentacyclic Core. T. Enomoto, Y. Yasui, Y. Takemoto, J. Org. Chem., 75(14), 4876-4879. 
  • Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation. Y. Yasui, H. Kamisaki, T. Ishida, Y. Takemoto, Tetrahedron, 66(10), 1980-1989 (2010). 
  • Br?nsted Acid―Thiourea Co-catalysis: Asymmetric Synthesis of Functionalized 1,4-Dihydropyridines from α-Enaminoesters and α,β-Unsaturated Aldehydes. K. Yoshida, T. Inokuma, K. Takasu, Y. Takemoto, Synlett, (12), 1865-1869 (2010). 
  • Concise Total Synthesis of (±)-Lycodine. C. Tsukano, L. Zhao, Y. Takemoto, M. Hirama, Eur. J. Org. Chem., (22), 4198-4200, (2010) 
    DOI:10.1002/ejoc.201000667 .
  • Synthesis of trifunctional thioureas bearing 1,5-disubstituted triazole tether by Ru-catalyzed Huisgen cycloaddition. K. Takasu, T. Azuma, Y. Takemoto, Tetrahedron Lett. 51(20), 2737-2740 (2010). 
  • Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine. N. Shindoh, Y. Takemoto, K. Takasu, Heterocycles in press.
  • Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. A. Kuwahara, M. Yamamori, K. Nishiguchi, T. Okuno, N. Chayahara, I. Miki, T. Tamura, K. Kadoyama, T. Inokuma, Y. Takemoto, T. Nakamura, K. Kataoka, T. Sakaeda, Int. J. Med. Sci., 7(1), 48-54(2010). 
  • Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions. Y. Takemoto, Chem. Pharm. Bull., 58(5), 593-601(2010). 
  • 有機ホウ素試薬を利用した不斉チオ尿素触媒反応の開発、竹本佳司、ファインケミカル、2010, 39(8), 22-32. 


  • Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Addition of α,β-Unsaturated Ketones with Alkenylboronic Acids. T. Inokuma, K. Takasu, T. Sakaeda, Y. Takemoto, Org. Lett., 11(11), 2425-2428 (2009). 
  • Atropisomerism of .alpha.,.beta.-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution. N. Shindoh, Y. Takemoto, K. Takasu, Chem. Eur. J., 15(29), 7026-7030 (2009). 
  • Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton. Y. Yasui, T. Kinugawa, Y. Takemoto, Chem. Commun., (28), 4275-4277 (2009). 
  • Gold(I)-Catalyzed Tandem Reactions Initiated by Hydroamination of Alkynyl Carbamates: Application to the Synthesis of Nitidine. T. Enomoto, A.-L. Girard, Y. Yasui, Y. Takemoto, J. Org. Chem., 74(23), 9158-9164 (2009). 
  • Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines: Convenient and Direct Modification of Guanidines. H. Miyabe, K. Yoshida, V. K. Reddy, Y. Takemoto, J. Org. Chem., 74(1), 305-311 (2009). 
  • Pd-catalyzed intramolecular amidation of 2-(buta-1,3-dienyl)phenylcarbamoyl chloride: a concise synthesis of spiro[indoline-3,3′-pyrrolidine]. H. Kamisaki, Y. Yasui, Y. Takemoto, Tetrahedron Lett., 50(21), 2589-2592 (2009). 
  • Synthesis of chiral oxime ethers based on regio- and enantioselective allylic substitution catalyzed by iridium-pybox complex. H. Miyabe, A. Matsumura, K. Yoshida, Y. Takemoto, Tetrahedron, 65(23), 4464-4470 (2009). 
  • Enantioselective nitrocyclopropanation of .alpha.,.beta.-unsaturated .alpha.-cyanoimides catalyzed by bifunctional thiourea. T. Inokuma, S. Sakamoto, Y. Takemoto, Synlett, (10), 1627-1630 (2009). 
  • Preparation of α,β-Unsaturated Lactams through Intramolecular Electrophilic Carbamoylation of Alkenes. Y. Yasui, I. Kakinokihara, H. Takeda, Y. Takemoto, Synthesis, (23), 3989-3993 (2009). 
  • Synthesis of indolo[2,3-b]quinolines by palladium-catalyzed annulation of unsaturated isothioureas. H. Takeda, T. Ishida, Y. Takemoto, Chem. Lett., 38(8), 772-773 (2009). 
  • Asymmetric Synthesis of 4-Substituted 2,6-Dioxopiperidine-3-carbonitrile by Using Thiourea-Catalyzed Asymmetric Michael Addition. T. Inokuma, Y. Nagamoto, S. Sakamoto, H. Miyabe, K. Takasu, Y. Takemoto, Heterocycles, 79(1), 573-582 (2009). 
  • Triflic Imide Catalyzed [3+2] Cycloaddition of Aldimines with α,α-Dimethylallylsilane. N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu, Heterocycles, 77(1), 187-192 (2009).
  • Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. A. Kuwahara, M. Yamamori, K. Nishiguchi, T. Okuno, N. Chayahara, I. Miki, T. Tamura, T. Inokuma, Y. Takemoto, T. Nakamura, K. Kataoka, T. Sakaeda, Int. J. Med. Sci., 6(6), 305-311 (2009). 
  • Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor. N. Shindoh, Y. Takemoto, K. Takasu, Chem. Eur. J., 15(45), 12168-12179 (2009). 
  • Triflic Imide Catalyzed Cycloaddition Reactions. K. Takasu, Synlett, (12), 1905-1914 (2009). 
  • インジウムを用いる合成反応の開発. 柳田玲子、竹本佳司, 有機合成化学協会誌, 67(3), 239-247 (2009).


  • Intra- and Intermolecular Amidation of C-C Unsaturated Bonds Through Palladium-Catalyzed Reactions of Carbamoyl Derivatives. Y. Yasui, Y. Takemoto, Chem. Rec. 8(6), 386-394 (2008).
  • Toward General Access to the Aspidosperma-Type Terpenoid Indole Alkaloids: Synthesis of the Key 3,3-Disubstituted Piperidones through Enantioselective Intramolecular Heck-Type Reaction of Chloroformamides. Y. Yasui, H. Takeda, Y. Takemoto, Chem. Pharm. Bull. 56 (11), 1567-1574 (2008).
  • Thiourea-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Azomethine Ylides with Nitroolefins. J. Xie, K. Yoshida, K. Takasu, Y. Takemoto, Tetrahedron Lett. 49(48), 6910-6913 (2008).
  • Discovery and Application of Asymmetric Reaction by Multi-Functional Thioureas. H. Miyabe, Y. Takemoto, Bull. Chem. Soc. Jpn. 81 (7), 785-795 (2008).
  • Auto-Tandem Catalysis in the Synthesis of Substituted Quinolines from Aldimines and Electron-rich Olefins: Cascade Povarov-Hydrogen Transfer Reaction. N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu, J. Org. Chem. 73(19), 7451-7456 (2008).
  • Enantioselective Synthesis of 3,3-Disubstituted Oxindoles through Pd-Catalyzed Cyanoamidation. Y. Yasui, H. Kamisaki, Y. Takemoto, Org. Lett. 10 (15), 3303-3306 (2008).
  • Gold(I)-Catalyzed Hydroamination as a General Approach toward the Synthesis of Substituted Hydroisoquinolines: Remarkable Acceleration by Ethanol. T. Enomoto, S. Obika, Y. Yasui, Y. Takemoto, Synlett (11), 1647-1650 (2008).
  • 連続反応および多成分反応を基盤とする多置換シクロブタンの迅速合成法の開発、高須清誠、有機合成化学協会誌、66 (6), 554-563, 2008.
  • Concise Synthesis of the CDE Ring System of Tetrahydroisoquinoline Alkaloids Using Carbophilic Lewis Acid-Catalyzed Hydroamidation and Oxidative Friedel-Crafts Cyclization. S. Obika, Y. Yasui, R. Yanada, Y. Takemoto, J. Org. Chem. 73 (13), 5206-5209 (2008).
  • Indium(III)-Catalyzed Tandem Reaction with Alkynylbenzaldehydes and Alkynylanilines to Heteroaromatic Compounds. R. Yanada, K. Hashimoto, R. Tokizane, Y. Miwa, H. Minami, K. Yanada, M. Ishikura, Y. Takemoto, J. Org. Chem. 73 (13), 5135-5138 (2008).
  • Enantioselective Synthesis of [1,2]-oxazinone scaffolds and [1,2]-oxazine core structures of FR900482. V. K. Reddy, H. Miyabe, M. Yamauchi, Y. Takemoto, Tetrahedron, 64 (6), 1040-1048 (2008).


  • Gold-Catalyzed Cyclization Reaction of Alkynyl tert-Butylcarbamates. H. Miyabe, Y. Sami, T. Naito, Y. Takemoto, Heterocyles, 73 (1), 187-190 (2007).
  • Chiral Thiourea-catalyzed Direct Mannich Reactions. Y. Yamaoka, H. Miyabe, Y. Yasui, Y. Takemoto, Synthesis, 2007 (16), 2571-2575 (2007).
  • Enantioselective Radical Cyclizations: A New Approach to Stereocontrol of Cascade Reactions. H. Miyabe, Y. Takemoto, Chem. Eur. J., 13 (26), 7280-7286 (2007).
  • Enantioselective Cascade Radical Addition-Cyclization of Oxime Ethers. H. Miyabe, A. Toyoda, Y. Takemoto, Synlett, 2007 (12), 1885-1888 (2007).
  • The Amino Thiourea-Catalyzed Asymmetric Nucleophilic Reactions. Y. Takemoto, H. Miyabe, Chimia, 61 (5), 269-275 (2007).
  • One-Pot Amidation of Olefins through Pd-Catalyzed Coupling of Alkylboranes and Carbamoyl Chlorides. Y. Yasui, S. Tuschida, H. Miyabe, Y. Takemoto, J. Org. Chem., 72 (15), 5898-5900 (2007).
  • Concise Synthesis of 1,2-Dihydroisoquinolines and 1H-Isochromones by Carbophilic Lewis Acid-Catalyzed Tandem Nucleophilic Addition and Cyclization of 2-(1-Alkynyl)arylaldimines and 2-(1-Alkynyl)aryaldehydes. S. Obika, H. Kono, Y. Yasui, R. Yanada, Y. Takemoto, J. Org. Chem., 72 (12), 4462-4468(2007).
  • Catalytic Enantioselective Petasis-Type Reaction of Quinolines Catalyzed by a Newly Designed Thiourea Catalyst. Y. Yamaoka, H. Miyabe, Y. Takemoto, J. Am. Chem. Soc, 129 (21), 6686-6687 (2007).
  • Intramolecular Cyanoamidation of Unsaturated Cyanoformamides Catalyzed by Palladium: An Efficient Synthesis of Multi-Functionalized Lactams. Y. Kobayashi, H. Kamisaki, H. Takeda, Y. Yasui, R. Yanada, Y. Takemoto, Tetrahedron, 63 (14), 2978-2989 (2007).


  • Development of Amino Thiourea Catalysts as an Artificial Enzyme: Their Application to Catalytic Enantioselective Reactions. Y. Takemoto, J. Synth. Org. Chem. Jpn., 64 (11), 1139-1147 (2006).
  • C-N Bond Formation through Amination. In Comprehensive Organometallic Chemistry III. Y. Takemoto, H. Miyabe; Eds. Crabtree, R. H.; Mingos, D. M. P.; Elsevier: Oxford, Vol. 10.15, 695-724. (2006).
  •  Reaction of Nitro Organic Compounds Using Thiourea Catalysts Anchored to Polymer Support. H. Miyabe, S. Tuchida, M. Yamauchi, Y. Takemoto, Synthesis, (19), 3295-3300 (2006).
  • Enantioselective Cascade Radical Addition-Cyclization-Trapping Reactions. H. Miyabe, R. Asada, A. Toyoda, Y. Takemoto, Angew. Chem. Int. Ed., 45 (35), 5863-5866 (2006).
  • Thiourea-Catalyzed Asymmetric Michael Addition of Activated Methylene Compounds to????-Unsaturated Imides: Dual Activation of Imide by Intra- and Intermolecular Hydrogen-bonding. T. Inokuma, Y. Hoashi, Y. Takemoto, J. Am. Chem. Soc., 128 (29), 9413-9419 (2006). 
  • Palladium-Catalyzed Intramolecular Cyanoamidation of Alkynyl and Alkenyl Cyanoformamides. Y. Kobayashi, H. Kamisaki, R. Yanada, Y. Takemoto, Org. Lett., 8 (13), 2711-2713 (2006).
  • Efficient Synthesis of Indoles Using [3,3]-Sigmatropic Rearrangement of N-Trifluoroacetyl Enehydrazines. O. Miyata, N. Takeda, Y. Kimura, Y. Takemoto, N. Tohnai, M. Miyata, T. Naito, Tetrahedron, 62 (15), 3629-3647 (2006).
  •  In(OTf)3-catalyzed Tandem Nucleophilic Addition and Cyclization of ortho-Alkynylarylaldimines to 1,2-Dihydroisoquinolines. R. Yanada, S. Obika, H. Kono, Y. Takemoto, Angew. Chem. Int. Ed., 45 (23), 3822-3825 (2006).
  • Reactive Ketimino Radical Acceptors: Intermolecular Alkyl Radical Addition to Imines with a Phenolic Hydroxyl Group. H. Miyabe, Y. Yamaoka, Y. Takemoto, J. Org. Chem., 71 (5), 2099-2106 (2006).
  • Organocatalytic Enantioselective Hydrazination of 1,3-Dicarbonyl Compounds: Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids. X. Xu, T. Yabuta, P. Yuan, Y. Takemoto, Synlett, (1), 137-140 (2006).
  • Bifunctional Thiourea-Catalyzed Diastereo- and Enantioselective Aza-Henry Reaction. X. Xu, T. Furukawa, T. Okino, H. Miyabe, Y. Takemoto, Chem. Eur. J., 12, 466-476 (2006).
  • Enantioselective Tandem Michael Reaction to Nitroalkene Catalyzed by Bifunctional Thiourea: Total Synthesis of (-)-Epibatidine. Y. Hoashi, T. Yabuta, P. Yuan, H. Miyabe, Y. Takemoto, Tetrahedron, 62 (2-3), 365-374 (2006).
  • 生物活性物質の迅速合成を指向した金属反応剤によるラクタム形成反応の開発 安井義純, 竹本佳司, 化学工業, 57 (19), 729-733 (2006).
  • チオ尿素系不斉有機分子触媒の創製「有機分子触媒の新展開」 竹本佳司, 監修 柴崎正勝, シーエムシー出版, Tokyo, 167-179 (2006).


  • Enantio- and Diastereoselective Michael Reaction of 1,3-Dicarbonyl Compounds to Nitroolefins Catalyzed by a Bifunctional Thiourea. T. Okino, Y. Hoashi, T. Furukawa, X. Xuenong, Y. Takemoto, J. Am. Chem. Soc., 127 (1), 119-125 (2005).
  • Enantioselective Michael Addition to α,β-Unsaturated Imides Catalyzed by a Bifunctional Organocatalyst. Y. Hoashi, T. Okino, Y. Takemoto, Angew. Chem. Int. Ed., 44 (26), 4032-4035 (2005).
  • Recognition and Activation by Ureas and Thioureas: Stereoselective Reactions Using Ureas and Thioureas as Hydrogen-Bonding Donors. Y. Takemoto, Org. Biomol. Chem., 3 (24), 4299 – 4306 (2005).
  • Regio- and Stereocontrolled Palladium or Iridium-Catalyzed Allylation. H. Miyabe, Y. Takemoto, Synlett, (11), 1641-1655 (2005).
  • A Convenient Synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by Rhodium-Catalyzed Intramolecular Hydroamidation, Y. Kobayashi, H. Kamisaki, K. Yanada, R. Yanada, Y. Takemoto, Tetrahedron Lett., 46, 7549-7532 (2005).
  • Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometallation and Pd-Catalyzed Cross-Coupling Reaction. R. Yanada, S. Obika, Y. Kobayashi, T. Inokuma, M. Oyama, Y. Takemoto, Adv. Synth. Cat., 347, 1632-1642 (2005).
  • Stereoselective Synthesis of 3-Alkylideneoxindoles via Palladium-Catalyzed Domino Reactions, R. Yanada, S. Obika, T. Inokuma, K. Yanada, M. Yamashita, S. Ohta, Y. Takemoto, J. Org. Chem. 70 (17), 6972-6975 (2005).
  • New utilization of optically active homoallylamines: Highly stereoselective synthesis of cyclic guanidine and thiourea, R. Yanada, A. Kaieda, K. Yanada, Y. Takemoto, Heterocycles, 66, 101-106 (2005).
  • Selective Synthesis of Allylated Oxime Ethers and Nitrones Based on Palladium-Catalyzed Allylic Substitution of Oximes. H. Miyabe, K. Yoshida, V. K. Reddy, A. Matsumura, Y. Takemoto, J. Org. Chem., 70 (14), 5630-5635 (2005).
  • Triethylborane-Induced Intermolecular Radical Addition to Ketimines. H. Miyabe, Y. Yamaoka, Y. Takemoto, J. Org. Chem., 70 (8), 3324-3327 (2005).
  • Hydroxylamines as Oxygen Atom Nucleophiles in Transition-Metal-Catalyzed Allylic Substitution. H. Miyabe, K. Yoshida, M. Yamauchi, Y. Takemoto, J. Org. Chem., 70 (6), 2148-2153 (2005).
  • Asymmetric Synthetic Study of Macrolactin Analogues. Y. Kobayashi, A. Fukuda, T. Kimachi, M. Ju-ichi, Y. Takemoto, Tetrahedron, 61 (10), 2607-2622 (2005).
  •  Synthesis of α,α-Disubstituted Amino Acids Based on Tandem Reaction of Dehydroamino Acid Derivatives. H. Miyabe, R. Asada & Y. Takemoto, Tetrahedron, 61 (1), 385-393 (2005).


  • Antiproliferative Activity of Rhinocanthus nasutus (L.) Kurz Extracts and the Active Moiety, Rhinacanthin C. A. Gotoh, T. Sakaeda, T. Kimura, T. Shirakawa, Y. Wada, A. Wada, T. Kimachi, Y. Takemoto, A. Iida, S. Iwakawa, M. Hirai, H. Tomita, N. Okamura, T. Nakamura, K. Okumura, Biol. Pharm. Bull., 27 (7), 1070-1074 (2004).
  • Bifunctional Thiourea-Catalyzed Enantioselective Double Michael Reaction of γ,δ-Unsaturated -Ketoester to Nitroalkene: Asymmetric Synthesis of (-)-Epibatidine. Y. Hoashi, T. Yabuta, Y. Takemoto, Tetrahedron Lett., 45 (50), 9185-9188 (2004).
  • Asymmetric Synthesis of Macrolactin A Analogue. Y. Kobayashi, A. Fukuda, T. Kimachi, M. Ju-ichi, Y. Takemoto, Tetrahedron. Lett., 45 (4), 677-680 (2004).
  • Free Radical-Mediated Tandem Reaction of Dehydroamino Acid Derivative with π-Allyl Palladium Complex: Synthesis of α,α-Disubstituted Amino Acids. H. Miyabe, R. Asada, K. Yoshida, Y. Takemoto, Synlett, (3), 540-542 (2004).
  • Utility of the Iridium Complex of the Pybox Ligand in Regio- and Enantioselective Allylic Substitution. H. Miyabe, A. Matsumura, K. Moriyama, Y. Takemoto, Org. Lett., 6 (24), 4631-4634 (2004).
  • Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines Having Electron-Withdrawing Substituents. H. Miyabe, A. Matsumura, K. Yoshida, M. Yamauchi, Y. Takemoto, Letters in Organic Chemistry, 1 (2), 119-121 (2004).
  • Novel Synthesis of O-Allylated Oxime Ethers Based on Allylic Substitution with Oximes. H. Miyabe, A. Matsumura, K. Yoshida, M. Yamauchi, Y. Takemoto, Synlett, (12), 2123-2126 (2004).
  • Aqueous Medium Radical Addition to Ketimines with a Phenolic Hydroxyl Group. H. Miyabe, Y. Yamaoka, Y. Takemoto. Synlett, (14), 2597-2599 (2004).
  • Palladium-Indium Iodide-Mediated Allylation and Propargylation of Glyoxylic Oxime Ether and Hydrazone: The Role of Water in Directing the Diastereoselective Allylation. H. Miyabe, Y. Yamaoka, T. Naito, Y. Takemoto, J. Org. Chem., 69 (4), 1415-1418 (2004).
  • Stereodivergent Synthesis of Chiral 2-Alkenylaziridines: Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination. H. Ohno, Y. Takemoto, N. Fujii, T. Tanaka, T. Ibuka, Chem. Pharm. Bull., 52 (1), 111-119 (2004).
  • Enantioselective Aza-Henry Reaction Catalyzed by Bifunctional Organocatalyst. T. Okino, S. Nakamura, T. Furukawa, Y. Takemoto, Org. Lett., 6 (4), 625-627 (2004).
  • Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation. R. Yanada, N. Nishimori, A. Matsumura, S. Obika, H. Mitsuya, N. Fujii, Y. Takemoto, J. Org. Chem., 67 (7), 2417-2422 (2004).
  • Indium-Mediated Radical Cyclization of Iodoalkenes and Iodoalkynes with and without Allylic and Propargylic Leaving Groups. R. Yanada, S. Obika, N. Nishimori, M. Yamauchi, Y. Takemoto, Tetrahedron Lett., 45 (11), 2331-2334 (2004).
  • Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometallation and Pd-Catalyzed Coupling Reaction. R. Yanada, S. Obika, M. Oyama, Y. Takemoto, Org. Lett., 6 (16), 2825-2828 (2004).
  • 分子不斉を構築する機能性分子 竹本佳司 ファルマシア, 40 (6), 499-501 (2004).


  • Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts. T. Okino, Y. Hoashi, Y. Takemoto, J. Am. Chem. Soc., 125 (42), 12672-12673 (2003).
  • Enantio- and Diastereoselective Ir-Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives. T. Kanayama, K. Yoshida, H. Miyabe, Y. Takemoto, Angew. Chem. Int. Ed., 42 (18), 2054-2056 (2003).
  • Synthetic Studies on Macrolactin A by Using a (Diene)Fe(CO)3 Complex. A. Fukuda, Y. Kobayashi, T. Kimachi, Y. Takemoto, Tetrahedron, 59 (47), 9305-9313 (2003).
  • Synthesis of β-Substituted α-Amino Acids Using Iridium-Catalyzed Asymmetric Allylic Substitution. T. Kanayama, K. Yoshida, H. Miyabe, T. Kimachi, Y. Takemoto, J. Org. Chem., 68 (16), 6197-6201 (2003).
  • Regioselectivity in Palladium-Indium Iodide-Mediated Allylation Reaction of Glyoxylic Oxime Ether and N-Sulfonylimine. H. Miyabe, Y. Yamaoka, T. Naito, Y. Takemoto, J. Org. Chem., 68 (17), 6745-6751 (2003).
  • Synthesis of azacycles based on Iridium-catalyzed sequential allylic amination. H. Miyabe, K. Yoshida, Y. Kobayashi, A. Matsumura, Y. Takemoto, Synlett, (7), 1031-1033 (2003).
  • O-Allylic Substitution of Hydroxylamine Derivatives Having an N-Electron-Withdrawing Substituent. H. Miyabe, K. Yoshida, A. Matsumura, M. Yamauchi, Y. Takemoto, Synlett, (4), 567-569 (2003).
  • Thiourea-Catalyzed Nucleophilic Addition of TMSCN and Ketene Silyl Acetals to Nitrones and Aldehydes. T. Okino, Y. Hoashi, Y. Takemoto, Tetrahedron Lett., 44 (14), 2817-2821 (2003).
  • Indium-Mediated Tandem Radical Addition-Cyclization-Trap Reactions in Aqueous Media. M. Ueda, H. Miyabe, A. Nishimura, O. Miyata, Y. Takemoto, T. Naito, Org. Lett., 5 (21), 3835-3838 (2003).
  • イミン類への炭素ラジカル付加反応の開発 宮部豪人 薬学雑誌, 123 (5), 285-294 (2003).


  • Asymmetric Synthesis of β2,3-Amino Acids by InI-Pd(0)-Promoted Metalation and Addition of Chiral 2-Vinylaziridines. M. Anzai, R. Yanada, N. Fujii, H. Ohno, T. Ibuka, Y. Takemoto, Tetrahedron, 58 (26), 5231-5239 (2002).
  • Synthetic Study on CP-263,114 (Phomoidride B) by SET-Mediated Fragmentation. T. Matsushita, H. Ashida, T. Kimachi, Y. Takemoto, Chem. Commun., (8), 814-815 (2002).
  • Pd-Catalyzed Asymmetric Allylic Alkylation of Glycine Iminoester Using a Chiral Phase-Transfer Catalyst. M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, J. Org. Chem., 67 (21), 7418-7423 (2002).
  • Synthesis of Allenes from Allylic Alcohol Derivatives Bearing a Bromine Atom Using a Palladium(0)/Diethylzinc System. H. Ohno, K. Miyamura, T. Tanaka, S. Oishi, A. Toda, Y. Takemoto, N. Fujii, T. Ibuka, J. Org. Chem., 67 (4), 1359-1367 (2002).
  • Indium-Mediated Atom-Transfer Cyclizations and Reductive Cyclizations. R. Yanada, N. Nishimori, A. Matsumura, N. Fujii, Y. Takemoto, Tetrahedron Lett., 43 (26), 4585-4588 (2002).
  • OsO4-Catalyzed Dihydroxylation of Olefins in Ionic Liquid [emim]BF4: A Recoverable and Reusable Osmium. R. Yanada, Y. Takemoto, Tetrahedron Lett., 43 (38), 6849-6852 (2002).
  • キレーション効果を利用したC-HおよびC-C結合の触媒的活性化 宮部 豪人 化学, 57 (9), 66-67 (2002).


  • Asymmetric Total Synthesis of Halicholactone. Y. Baba, G. Saha, S. Nakao, C. Iwata, T. Tanaka, T. Ibuka, H. Ohishi, Y. Takemoto, J. Org. Chem., 66 (1), 81-88 (2001).
  • Novel Sparteine-Mediated Enantio-Dichotomic Formal Synthesis of (R)-(-)- and (S)-(+)-Curcuphenol. T. Kimachi, Y. Takemoto, J. Org. Chem., 66 (8), 2700-2704 (2001).
  • Chiral Phosphine-Free Pd-Mediated Asymmetric Allylation of Prochiral Enolate with a Chiral Phase-Transfer Catalyst. M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, Org. Lett., 3 (21), 3329-3331 (2001).
  • Stereoselective Synthesis of 2-Alkenylaziridines and 2-Alkenylazetidines by Palladium-Catalyzed Intramolecular Amination of α- and β-Amino Allenes. H. Ohno, M. Anzai, A. Toda, S. Ohishi, N. Fujii, T. Tanaka, Y. Takemoto, T. Ibuka, J. Org. Chem., 66 (14), 4904-4914 (2001).
  • Role of the Planar Chirality of Chiral Amino Alcohols Bearing Iron Tricarbonyl in Asymmetric Alkylation of Diethylzinc to Aldehydes. K. Okamoto, T. Kimachi, T. Ibuka, Y. Takemoto, Tetrahedron: Asymmtry, 12 (3), 463-467 (2001).
  • Asymmetric Alkylation of tert-Butyl Glycinate Schiff Base with Chiral Quaternary Ammonium Salt under Micellar Conditions. T. Okino, Y. Takemoto, Org. Lett., 3 (10), 1515-1517 (2001).
  • Stereoselective Synthesis of Nonracemic 1,3-Amino Alcohols from Chiral 2-Vinylaziridines by InI-Pd(0)-Promoted Metalation. Y. Takemoto, M. Anzai, R. Yanada, N. Fujii, H. Ohno, T. Ibuka, Tetrahedron Lett., 42 (9), 1725-1728 (2001).
  • Stereospecific 1,3-Migration of an Fe(CO)3 Group on Acyclic Conjugated Polyenes: Application to Remote and Iterative Asymmetric Induction. Y. Takemoto, K. Ishii, T. Ibuka, Y. Miwa, T. Taga, S. Nakao, T. Tanaka, H. Ohishi, Y. Kai, N. Kanehisa, J. Org. Chem., 66, 6116-6123 (2001).
  • Diastereoselective Barbier-Type and Palladium-Mediated Allylaion of Optically Active Aldimine with Allylindium Reagents. R. Yanada, A. Kaieda, Y. Takemoto, J. Org. Chem., 66 (22), 7516-7518 (2001).
  • Aluminum-Controlled Reactivity and Diastereoselectivity Toward Radical Reactions of Optically Active Aldimines with Metallic Samarium. R. Yanada, M. Okaniwa, A. Kaieda, T. Ibuka, Y. Takemoto, J. Org. Chem., 66 (4), 1283-1286 (2001).


  • Stereoselective Synthesis of Chiral Amino Allenes by Organocopper-Mediated anti SN2′-Substitution Reaction of Chiral Ethynylaziridines. H. Ohno, A. Toda, N. Fujii, Y. Takemoto, T. Tanaka, T. Ibuka, Tetrahedron, 56 (18), 2811-2820 (2000).
  • Novel Synthesis of Chiral Terminal Allenes via Palladium(0)-Catalyzed Reduction of Mesylates of 2-Bromoalk-2-en-1-ols Bearing a Protected Amino Group, Using Diethylzinc. H. Ohno, A. Toda, S. Oishi, T. Tanaka, Y. Takemoto, N. Fujii, T. Ibuka, Tetrahedron Lett., 41 (26), 5131-5134 (2000).
  • Asymmetric Total Synthesis of Halicholactone. Y. Takemoto, Y. Baba, G. Saha, S. Nakao, C. Iwata, T. Tanaka, T. Ibuka, Tetrahedron Lett., 41 (19), 3653-3656 (2000).
  • Remote Asymmetric Induction by Using 1,3-Migration Reaction of (Diene)iron Tricarbonyl Complexes. Y. Takemoto, K. Ishii, A. Honda, K. Okamoto, R. Yanada, T. Ibuka, Chem. Commun., 1445-1446 (2000).
  • Enantioselective Addition of Diethylzinc to Aldehydes with Novel Chiral C2-Symmetric Dimeric Ligands. M. Okaniwa, R. Yanada, T. Ibuka. Tetrahedron Lett. 41 (7), 1047-1050 (2000).
  • Stereospecific 1,3-Migration of an Fe(CO)3 Group on Acyclic Conjugated Trienes Bearing an Electron-Withdrawing Group. Y. Takemoto, K. Ishii, Y. Miwa, T. Taga, T. Ibuka, S. Nakao, T. Tanaka, Tetrahedron Lett., 41 (1), 85-88 (2000).
  • オキシムエーテルをラジカル受容体とした固相ラジカル反応の開発 宮部 豪人 薬学雑誌, 120 (8), 667-676 (2000).
  • アルデヒドやケトンをラジカル受容体とするには 宮部 豪人 ファルマシア, 36, 407-408 (2000).
  • 金属サマリウムを利用する合成反応の開発 柳田玲子, 井深俊郎 有機合成化学協会誌, 58 (6), 597-605 (2000).


  • Utility of A Diene-tricarbonyliron Complex as A Mobile Chiral Auxiliary: Regio- and Stereocontrolled Functionalization of Acyclic Diene Ligands. Y. Takemoto, N. Yoshikawa, Y. Baba, C. Iwata, T. Tanaka, T. Ibuka, H. Ohishi, J. Am. Chem. Soc., 121 (39), 9143-9154 (1999).
  • Synthesis of Chiral Amino Allenes via an Organocyanocuprate-Mediated Ring-Opening Reaction of Enantiopure Ethynylaziridines. H. Ohno, A. Toda, Y. Miwa, T. Taga, N. Fujii, T. Ibuka, Tetrahedron Lett., 40 (2), 349-352 (1999).
  •  Stimulation of Nerve Growth Factor Synthesis/Secretion by 5-Deazaflavoquinone in Mouse Astrocytes. Tanigawa, H. Ohde, F. Yoneda, T. Kimachi, M. Toyomoto, S. Inoue, K. Ikeda, K. Hayashi, J. Biochem. Mol. Bio. & Biophys., 3, 231-237 (1999).
  • Sterically Congested Chiral Activated Aziridines: Synthesis of Both 2,3-Cis- and 2,3-Trans-2-Alkenyl-3-alkylaziridines from Common Intermediates. H. Ohno, A. Toda, N. Fujii, Y. Miwa, T. Taga, Y. Yamaoka, E. Osawa, T. Ibuka, Tetrahedron Lett., 40 (7), 1331-1334 (1999).
  • First Palladium-Catalyzed Aziridination Reaction of Amino Allenes. H. Ohno, A. Toda, Y. Miwa, T. Taga, N. Fujii, T. Ibuka, J. Org. Chem., 64 (9), 2992-2993 (1999).
  • Regiospecific Ring-Opening Reactions of β-Aziridinyl α,β-Enoates with Acids: Application to the Stereoselective Synthesis of a Couple of Diastereoisomeric (E)-Alkene Dipeptide Isosteres from a Single β-Aziridinyl α,β-Enoate and to the Convenient Preparation of Amino Alcohols Bearing α,β-Unsaturated Ester Groups. H. Tamamura, M. Yamashita, Y. Nakajima, K. Sakano, A. Otaka, H. Ohno, T. Ibuka, N. Fujii, J. Chem. Soc., Perkin Trans. 1, (20), 2983-2996 (1999).
  • Palladium-Catalyzed Regio- and Stereoselective Synthesis of N-Protected 2,4-Dialkylated Azacyclobutanes from Amino Allenes. M. Anzai, A. Toda, H. Ohno, Y. Takemoto, N. Fujii, T. Ibuka, Tetrahedron Lett., 40 (41), 7393-7397 (1999).
  • Selective Synthesis of Nonracemic 3-Pyrrolines and 2,3-Cis-2-vinylaziridines from (Z)-Amino Allylic Alcohols: A New Synthetic Route to Chiral 3,4-Dehydroproline. K. Ishii, H. Ohno, Y. Takemoto, T. Ibuka, Synlett, (2), 228-230 (1999).
  • Selective Synthesis of Cis-2-vinyl-3-alkylaziridines and 3-Pyrrolines from Common Intermediates (Z)-4-N-Arylsulfonylaminoalk-2-en-1-ols. K. Ishii, H. Ohno, Y. Takemoto, E. Osawa, Y. Yamaoka, N. Fujii, T. Ibuka, J. Chem. Soc., Perkin Trans.1, (15), 2155-2163 (1999).
  • Convenient Syntheses of Chiral 3-Substituted 2-Ethynylaziridines. H. Ohno, A. Toda, Y. Takemoto, N. Fujii, T. Ibuka, J. Chem. Soc., Perkin Trans. 1, (20), 2949-2962 (1999).
  • CAN Induced Double Ether Ring Formation: Synthesis of Trans- and Cis-fused Tricyclic Ethers from 3-Oxabicyclo[3.1.0]hexyl Sulfides. Y. Takemoto, S.-i. Furuse, H. Hayase, T. Echigo, C. Iwata, T. Tanaka, T. Ibuka, Chem. Commun., (24), 2515-2516 (1999).
  • Diastereoselective Allylation and Alkylation of Optically Active Imines with Metallic Samarium and A Catalytic Amount of Iodine. R. Yanada, N. Negoro, M. Okaniwa, T. Ibuka, Tetrahedron, 55 (49), 13947-13956 (1999).
  • Samarium-Promoted Diastereoselective Reductive Coupling of Optically Active Imines. R. Yanada, N. Negoro, M. Okaniwa, Y. Miwa, T. Taga, K. Yanada, T. Fujita, Synlett, (5), 537-540 (1999). 
  • Sparteine-Mediated Enantioselective [2,3]-Wittig Rearrangement of Allyl ortho-Substituted Benzyl Ethers and ortho-Substituted Benzyl Prenyl Ethers. T. Kawasaki, T. Kimachi, Tetrahedron, 55 (22), 6847-6862 (1999).